SYPHILIS – ANTIBIOTIC TREATMENT
Parenteral penicillin is the drug of choice. Alternative antibiotics should only be used where there is a history of penicillin sensitivity.
Early syphilis
Aqueous procaine penicillin G 1.5 g daily intramuscularly for a minimum of 10 days;
Benzathine penicillin G 1.8 g intramuscularly in a single dose for patients unable to comply with daily injections, preferably repeated 7 days later.
Late latent syphilis
Aqueous procaine penicillin G 1.5 g daily intramuscularly for 15 days; OR
Benzathine penicillin 1.8 g intramuscularly at 7 day intervals for 3 doses for patients unable to comply with daily injections.
Benign gummatous syphilis
Aqueous procaine penicillin G 1.5 g daily intramuscularly for 21 days; OR
Benzathine penicillin G 1.8 g intramuscularly at 7 day intervals for 3 doses for patients unable to comply with daily injections. This should never be used in late syphilis unless the CSF is negative.
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